帮我翻译一下这段英文,生物信息学方面的,谢谢Inspection of the amino acid-base interactions in protein-DNA complexes is essential to the understanding of specific recognition of DNA target sites by regulatory proteins. The accumulati

帮我翻译一下这段英文,生物信息学方面的,谢谢Inspection of the amino acid-base interactions in protein-DNA complexes is essential to the understanding of specific recognition of DNA target sites by regulatory proteins. The accumulati
帮我翻译一下这段英文,生物信息学方面的,谢谢
Inspection of the amino acid-base interactions in protein-DNA complexes is essential to the understanding of specific recognition of DNA target sites by regulatory proteins. The accumulation of information on protein-DNA co-crystals challenges the derivation of quantitative parameters for amino acid-base interaction based on these data. Here we use the coordinates of 53 solved protein-DNA complexes to extract all nonhomologous pairs of amino acid-base that are in close contact, including hydrogen bonds and hydrophobic interactions. By comparing the frequency distribution of the different pairs to a theoretical distribution and calculating the log odds, a quantitative measure that expresses the likelihood of interaction for each pair of amino acid-base could be extracted. A score that reflects the compatibility between a protein and its DNA target can be calculated by summing up the individual measures of the pairs of amino acid-base involved in the complex, assuming additivity in their contributions to binding. This score enables ranking of different DNA binding sites given a protein binding site and vice versa and can be used in molecular design protocols. We demonstrate its validity by comparing the predictions using this score with experimental binding results of sequence variants of zif268 zinc fingers and their DNA binding sites.
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帮我翻译一下这段英文,生物信息学方面的,谢谢Inspection of the amino acid-base interactions in protein-DNA complexes is essential to the understanding of specific recognition of DNA target sites by regulatory proteins. The accumulati
研究蛋白质-DNA复合体的氨基酸-碱基相互作用,对于我们理解调控蛋白对DNA靶点的特异性识别是很有必要的.
而在蛋白-DNA共结晶方法上的信息不断积累,则对以这些数据推导氨基酸-碱基相互作用的定性参数,提供了机遇.
在这里,我们利用53种已知的蛋白-DNA复合物,来提取所有非同源的紧密相连的氨基酸-碱基配对,包括氢键和疏水相互作用.
通过对不同配对的频率分布和理论分布的对比以及对对数比的计算,可以得到一种表示每对氨基酸-碱基作用的相似性的定量方法.
假设各氨基酸-碱基配对对蛋白-DNA结合的贡献是可加的,那么将蛋白-DNA复合物中的各个独立氨基酸-碱基对以这种方法进行评分,并进行加和,得到的总分就能够反映蛋白质和它的DNA靶点的兼容性.
这种评分可以通过对多个不同DNA结合位点进行分级,以给出一个蛋白质结合位点,反之亦然,同时还可以将它用于分子设计的步骤中.
我通过对以此评分预测的结果和实验得出的多个zif268锌指序列变体与它们的DNA结合位点的结果之间的比较,阐明了这种方法的正确性和可行性.
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