IL-21是什么?

IL-21是什么?
IL-21是什么?

IL-21是什么?
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Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells (leukocytes,hence the -leukin) as a means of communication (inter-).The name is something of a relic though (the term was coined by Dr.Paetkau,University of Victoria); it has since been found that interleukins are produced by a wide variety of bodily cells.The function of the immune system depends in a large part on interleukins,and rare deficiencies of a number of them have been described,all featuring autoimmune diseases or immune deficiency.
Name Source Function
IL-1 macrophages small amounts induce acute phase reaction,large amounts induce fever.
IL-2 TH1-cells stimulates growth and differentiation of T cell response.Can be used in immunotherapy to treat cancer or suppressed for transplant patients.
IL-3 T cells stimulates bone marrow stem cells
IL-4 TH2-cells,just activated naive CD4+ cell,memory CD4+ cells involved in proliferation of B cells and the development of T cells and mast cells.Important role in allergic response (IgE)
IL-5 TH2-cells role in differentiation of B cells,eosinophil production,and IgA production
IL-6 macrophages,TH2-cells induces acute phase reaction
IL-7 stromal cells of the red marrow and thymus involved in B,T,and NK cell survival,development,and homeostasis
IL-8 macrophages,epithelial cells,endothelial cells Neutrophil chemotaxis
IL-9 T-cells,specifically by CD4+ helper cells stimulates mast cells
IL-10 monocytes,TH2-cells,mast cells inhibits Th1 cytokine production
IL-11 bone marrow stroma acute phase protein production
IL-12 macrophages NK cell stimulation,Th1 cells induction.May suppress food allergies
IL-13 TH2-cells Stimulates growth and differentiation of B-Cells (IgE),inhibits TH1-cells and the production of macrophage inflammatory cytokines
IL-14 T cells and certain malignant B cells controls the growth and proliferation of B cells
IL-15 mononuclear phagocytes (and some other cells) following infection by virus(es).Induces production of Natural Killer Cells
IL-16 a variety of cells (including lymphocytes and some epithelial cells) chemoattracts immune cells expressing the cell surface molecule CD4
IL-17 - Induces production of inflammatory cytokines
IL-18 macrophages Induces production of Interferon-gamma (IFNγ)
IL-19 -
IL-20 - regulates proliferation and differentiation of keratinocytes
IL-21 -
IL-22 - Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A,Alpha 1-antichymotrypsin and haptoglobin in hepatoma cell lines
IL-23 - Increases angiogenesis but reduces CD8 T-cell infiltration
IL-24 - Plays important roles in tumor suppression,wound healing and psoriasis by influencing cell survival.
IL-25 - Induces the production IL-4,IL-5 and IL-13,which stimulate eosinophil expansion
IL-26 - Enhances secretion of IL-10 and IL-8 and cell surface expression of CD54 on epithelial cells
IL-27 - Regulates the activity of B lymphocyte and T lymphocytes
IL-28 - Plays a role in immune defense against viruses
IL-29 - Plays a role in host defenses against microbes
IL-30 - Forms one chain of IL-27
IL-31 - May play a role in inflammation of the skin
IL-32 - Induces monocytes and macrophages to secrete TNF-α,IL-8 and CXCL2
IL-33 - Induces helper T cells to produce type 2 cytokines
Interleukin 21 (IL-21),is a cytokine that has potent regulatory effects on cells of the immune system,including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.[1][2] This cytokine induces cell division/proliferation in its target cells.IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor,IL-21R,that is expressed in bone marrow cells and various lymphocytes.

答：IL-21是IL-2家族中的新成员,主要是由活化的CD4+T细胞分泌的,具有广泛的生物学功能,主要表现为免疫调节功能,其中最显著的特征是能增强效应T细胞及活化的NK细胞的功能,包括增强胞毒活性及促使分泌IFN-γ,从而有效增强机体的天然免疫以及特异性免疫,促使荷瘤动物产生较强的抗肿瘤免疫效应.
谢谢！...

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答：IL-21是IL-2家族中的新成员,主要是由活化的CD4+T细胞分泌的,具有广泛的生物学功能,主要表现为免疫调节功能,其中最显著的特征是能增强效应T细胞及活化的NK细胞的功能,包括增强胞毒活性及促使分泌IFN-γ,从而有效增强机体的天然免疫以及特异性免疫,促使荷瘤动物产生较强的抗肿瘤免疫效应.
谢谢！

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IL-21是一种新发现的细胞因子,结构上与IL-2、IL-15相似,可调控T细胞、B细胞增殖,影响NK细胞的分化成熟及其胞毒效应,并参与造血系统的发育;其受体IL-21R 与部分细胞因子共用γ链(γc),可能参与性连锁严重联合免疫缺陷(XSCID)的发病.

人白细胞介素家族的新成员